Abstract: Drug repositioning in cancer has been pursued for years because of slowing drug development, increasing costs, and the availability of drugs licensed for other indications with anticancer effects in the laboratory. Repositioning has encountered obstacles due to generally insufficient single-agent clinical anticancer effects of licensed drugs and a subsequent reluctance by pharmaceutical companies to invest in phase III combination studies with them. Here we review potential machine learning/artificial intelligence (ML/AI) approaches for using real-world data (RWD) that could overcome the limitations of clinical trials and retrospective analyses. We outline a two-tiered filtering approach of identifying top-ranked drugs based on their drug-target binding affinity scores while considering their challenges and matching the top-ranked drugs with their top-ranked specific scenarios from among the multitude of real-world scenarios for efficacy and safety. This approach will generate RWD scenario-specific hypotheses that can be tested in randomized clinical trials with high probabilities of success.
FGF Receptor Signaling in Breast Cancer Dormancy and Reawakening in the Bone Marrow
Dr. Nabil Adam is a Co-PI of a new research grant proposal that the Department of Defense has approved for a three-year study on the role of the FGF receptor in the dormant state of breast cancer cells. This project aims to identify the factors that can trigger the cancer cells’ reemergence and prevent it from returning. The findings of this study could help improve the detection and treatment of breast cancer. He plans to pursue this project with the help of Rutgers New Jersey Medical School and the Albert Einstein College of Medicine.
The Immutable Burden of Racial Disparities in Breast Cancer
Dr. Nabil Adam (Ph.D.) and Dr. Robert Wieder (M.D., Ph.D.) Awarded 2020 Busch Biomedical Grant
Dr. Nabil Adam Invited to Engineering for One Planet Scaling for Impact Workshop
From June 21 to 24, 2022, Dr. Nabil Adam will be participating in a workshop organized by the National Science Foundation’s Engineering for One Planet initiative. The event will bring together various engineering faculty members, students, and professional engineers to discuss how to improve the quality of engineering education in the US. The workshop participants will then develop a 5-year roadmap to transform the country’s engineering curriculum.